Aer Lingus will launch flights from Dublin to Santorini next summer.
Twice-weekly flights will get under way on 1 May, with the route operating through to 25 September.
One-way fares, including taxes and charges, lead in from €79.99 (£72).
Aer Lingus will also fly to Rhodes, Corfu and Athens next summer.
Chief commercial officer David Shepherd said he hoped the announcement would give Irish holidaymakers "something to look forward to".
"With the encouraging developments regarding vaccines and the introduction of improved testing regimes, we are gearing up for a busy summer ahead.
"Our customers can book their summer holidays with confidence thanks to our flexible booking options, and travel in the knowledge that the airline prioritises the safety and wellbeing of our customers and our people at all times.”