The vessel was due to resume in July but positive Covid-19 tests among a "small number" of crew members forced the line to postpone its Southampton sailings for a month.
Queen Elizabeth will initially offer a series of UK voyages before resuming international operations in October with a cruise from Southampton to Amsterdam.
The ship will sail a 14-night voyage to the Canary Islands and Madeira in November.
Cunard president Simon Palethorpe said the line is "delighted" to welcome guests back onboard.
