The 2,668-guest vessel was delivered in July 2021 and is HAL’s third Pinnacle-class ship.
Last week, it arrived at its namesake city of Rotterdam where it was announced that Princess Margriet of the Netherlands will be the ship’s godmother when it is officially named in the spring.
HAL president Gus Antorcha said the maiden voyage had been "highly anticipated for months" by guests and team members.
"Rotterdam is a beautiful ship and the fourth in our fleet to begin cruising this year," he added. "We are excited to bring her to Florida and the Caribbean soon on her first sailing."