Twice-weekly flights to the Turkish holiday hotspot will get under way on 26 March 2021.
Frequency will increase to four-times-weekly from 30 May. Fares are on sale now.
Peter Glade, chief commercial officer of SunExpress, a Lufthansa-Turkish Airlines joint venture, said the operation would offer a fast and competitively priced service.
Manchester airport managing director Karen Smart added: "After a difficult year, the route will mean families and households across our vast catchment will have additional access to one of our most popular summer destinations."
