EasyJet will be connecting Liverpool with Antalya in time for summer 2020.
The new weekly route will operate each Thursday next summer from its launch on 2 April and is predicted to carry 8,000 customers over the summer.
Once up and running, it will be the 33rd destination the airline operates to and from the airport.
EasyJet UK country manager Ali Gayward said: “As the largest airline at Liverpool, we’re focused on strengthening our network and providing our customers in the north west with excellent services by offering great value fares, a convenient schedule and more choice when they travel.”
Liverpool John Lennon airport chief executive John Irving added: “Holidays to Turkey are popular with passengers from across the north west and north Wales, who now have the opportunity to fly from Liverpool with easyJet to the three main Turkish Mediterranean holiday destinations, with this new route complementing the airline’s existing services to Dalaman and Bodrum.”