Qatar Airways is to start flying between Birmingham and Doha from March, 2016.
The airline will operate eight flights a week, including two on Saturdays.
Qatar Airways already flies from Heathrow, Manchester and Edinburgh airports.
The route will be operated by a Boeing 787 Dreamliner, which has a two-cabin configuration, comprising of 22 seats in Business Class and 232 Economy Class seats.
Qatar Airways group chief executive, Akbar Al Baker said: “This additional route strengthens Qatar Airways’ commitment to the regions across the UK and will create new commercial and leisure links between the city of Birmingham and the 152 destinations served by the airline.”
Birmingham Airport chief executive, Paul Kehoe said: “This is fantastic news for both Birmingham Airport and the region, and is our tenth new airline to announce or launch this year.
"Not only will our passengers have the choice of flying with the award winning carrier to Doha’s state-of-the-art hub Hamad International Airport, they will have a choice of 152 destinations served by the airline, including South East Asia, China and Australasia.”