Wizz Air will launch four new leisure routes from Gatwick airport in October, flying to Greece, Italy, Spain and Malta.
The budget carrier will base a single Airbus A321 aircraft at the Sussex airport, with flights starting from 22 October.
New destinations include Lanzarote, Athens, Naples and Valletta.
Wizz has operated from Gatwick since 2016, but it is the first time the carrier has based an aircraft at the airport.
It says the move will offer 450,000 seats a year, create more than 40 jobs and indirectly support upwards of 125 roles in the Gatwick catchment.
Fares lead in from £21.99pp one-way and are on sale now.