Chief executive Steve Heapy said the company is seeing aircraft "emptying" on routes to the eastern Mediterranean, although demand for western Mediterranean destinations remains strong.
Heapy had been due to attend the annual Jet2 conference in Cadiz, Spain, but said he was unable to travel after remaining in London for meetings with officials, including those from the Department for Transport and the UK Civil Aviation Authority, to discuss the operational impact of the conflict.
Speaking via a recorded message to 350 agents, Heapy said: "Bookings to Cyprus and Turkey are drying up, cancellations are up and our aircraft are emptying."