Passengers on select BA and American flights to Heathrow from Dallas Fort Worth, New York JFK and Los Angeles will be able to opt into the testing trial, starting 25 November, which will involve three tests throughout their journey.
If they test positive at any stage, they will have to reschedule or cancel their travel.
The first test will be taken 72 hours before departure using an at-home RT-PCR nasal test provided by LetsGetChecked, guided virtually by a medical professional.