The inaugural service to Dublin, operated by Loganair, was blessed by the Archdeacon of Carlisle, the Venerable Lee Townend.
Besides Dublin, Loganair has committed to operating routes to Southend airport and Belfast City airport.
The former RAF airfield, now owned and operated by Stobart Group, has been upgraded with a new terminal, cafe, office complex, additional car parking and access, as well as new runways and taxiways.
Flights had been due to resume in June last year but the relaunch was delayed due to a shortage of air traffic control staff and regulatory matters arising from planned construction works.
