Former Tui aviation chief Browne assumed the role with easyJet in October 2016 following a stint on the airline’s board.
She previously headed up First Choice Airways and Thomson Airways.
David Morgan has been appointed interim head of operations at easyJet, while Browne will remain available to easyJet through to the end of June.
EasyJet chief executive Johan Lundgren said: “Chris has contributed immensely to the airline in her time with us here and I am very grateful for all her dedication, hard work and inspirational leadership.”
Browne was awarded an OBE for services to travel in 2013 and took time out to share her career insights and champion TTG’s 30 Under 30 programme in February 2017.