The carrier on Tuesday (19 November) set out its summer 2020 flying programme from Heathrow.
It includes a new weekly Friday flight to San Francisco, boosting the service to twice-daily.
Virgin will deploy its new Airbus A350 aircraft on the route from May 2020 which, when coupled with the new weekly flight, will increase capacity by 40,000 seats for the summer season.
It has also announced it will deploy the A350 on routes to Johannesburg, Los Angeles and Lagos.
From March, Virgin will operate a daily Heathrow-Johannesburg A350 service. In April, the A350 will fly daily to Los Angeles and daily to Lagos from August.
