Virgin Atlantic will launch a new Heathrow-St Vincent service next summer.
Twice-weekly flights will get under way in June 2021, Virgin confirmed on Tuesday (3 November).
The route will be operated by an Airbus A330-300 aircraft offering 31 upper, 48 premium and 185 economy seats.
Besides its own sandy beaches, St Vincent also serves as a gateway to the 32 islands of the Grenadines.
Fares will go on sale on 24 November.
Juha Jarvinen, Virgin Atlantic chief commercial officer, said: “We’re delighted to launch the first flight from Europe to St Vincent and the Grenadines with our new twice-weekly service planned to launch from June 2021.
“St Vincent and the Grenadines, as well as the Caribbean region as a whole, represent an extremely exciting opportunity for us.
"With many islands implementing rigorous Covid-19 protocols, including testing before arrival and a short quarantine period for visitors, the islands are open for tourism and are a haven for travellers in search of sun."
Virgin currently flies to Barbados, Antigua, Jamaica and Grenada in the Caribbean.
Jarvinen added he was hopeful Virgin would be able to restart Tobago flights in the coming months.
Glen Beache, chief executive of the St Vincent and the Grenadines Tourism Authority, said: “It is only fitting the most diverse destination in the Caribbean works with one of the best airlines in Europe.
"This partnership will not only change the way in which potential visitors look at us, but it will also play a big role in the number of times the diaspora visit their home yearly.
"The arrival of Virgin Atlantic will have a positive and lasting effect on the product that is St Vincent and the Grenadines."