The Ethiopian Airlines service launches on December 1 and will be operated four times a week on board a Boeing 787.
The airline’s chief executive Tewolde Gebremariam said passengers taking the flight, which lands in the Ethiopian capital at 6am, will then be well placed to take advantage of the airlines many onwards connections.
He added: "It will be the only and first direct flight from Manchester to the heart of Africa and with connecting flights."
Gebremariam said the flight would save people living in the north of the UK from having to travel to London to catch a flight.
