The tourism board has released details of the seven itineraries running from April 26 to May 4 100 agents can win places on.
They will then gather in Nashville for the finale celebration where they will also get the opportunity to share their new-found knowledge with the rest of the group.
The seven itineraries are:
To be eligible to win a place on the MegaFam, travel agents in the UK and Ireland must book travellers on American Airlines and British Airways flights to the United States during the entry period from 1 December 1, 2017, until March 23, 2018.
In addition, they must earn as many badges as possible on Brand USA’s official agent USA Discovery Program training site, including the mandatory MegaFam Airlines 2018 badge and the Music, Culture and Heritage badge.
Agents can also enter the competition on the site too.