EasyJet will resume a limited flight programme next month where there is "sufficient customer demand to support profitable flying".
The schedule will mainly comprise UK domestic and French routes, with more to be announced over the coming weeks as demand increases and European lockdown measures are relaxed.
No additional details of the routes easyJet plans to operate from the outset have yet been disclosed.
Flights will be operated according to strict new safety and sanitation guidelines, with passengers, cabin crew and ground staff required to wear masks.
Aircraft will be subject to enhanced cleaning and disinfection; disinfectant wipes and hand sanitiser will be available onboard; and there will initially be no onboard food service.
EasyJet said the measures had been devised and implemented in consultation with the International Civil Aviation Organization and European Aviation Safety Agency, and in line with government and medical advice.
It has also pledged to continue guiding passengers towards its app to reduce interactions during the airport journey, such as by boarding using digital boarding passes.
"These are small and carefully planned steps that we are taking to gradually resume operations," said easyJet chief executive Johan Lundgren.
"We will continue to closely monitor the situation across Europe so that when more restrictions are lifted the schedule will continue to build over time to match demand, while also ensuring we are operating efficiently and on routes that our customers want.
"The safety and wellbeing of our customers remains our highest priority, which is why we are implementing a number of measures to enhance safety at each part of the journey, from disinfecting the aircraft to requiring customers and crew to wear masks.
"These measures will remain in place for as long as is needed to ensure customers and crew are able to fly safely as the world continues to recover from the impact of the coronavirus pandemic."