Stobart Air, which operates Aer Lingus Regional, will deploy five ATR72-600 aircraft at the airport, flying to Edinburgh, Manchester, Birmingham, East Midlands, Leeds Bradford and Exeter.
Edinburgh flights will get under way on 27 August. Flights to Exeter will start on 28 August, with Manchester and Birmingham following on 14 September. Services to East Midlands and Leeds Bradford will launch on 1 October.
Stobart plans to operate more than 200 weekly flights to and from Belfast City, offering "convenient flight times" to ensure "essential connectivity" between Northern Ireland and the UK.