The two men were seen entering the Cook shop on Manchester Fort, just off Cheetham Hill Road, at about 5pm the Manchester Evening News reports.
The assailants are said to have smashed through the window of the bureau de change – with a staff member sat behind it – during the attempted robbery.
Thankfully, police and security staff were alerted, chased the men, and they were unable to escape with any money.
One eyewitness said there were customers in the store at the time of the incident.
A Thomas Cook spokesperson said: “We can confirm that an attempted robbery took place at our Thomas Cook store in Manchester earlier today.