The Scottish carrier took over the daily London City route from British Airways at the start of September on an interim basis.
From 1 December, however, flights will instead operate from Heathrow, offering travellers a greater range of connections.
The route is Loganair’s first permanent scheduled service to and from Heathrow, and will be operated using a 49-seat Embraer 145 jet.
Fares lead in from £69.99pp one way, with Saturday flights set to be introduced from 19 December.
During winter 2020/21, flights Monday to Thursday will depart the Isle of Man at 6.50am, arriving Heathrow at 8.05am. The return flight will depart Heathrow at 8.50am, arriving Isle of Man at 10.05am.
From 19 December, on Saturdays, flights will depart Isle of Man at 7.05am, arriving Heathrow at 9.10am. Returns will depart Heathrow at 10am, arriving Isle of Man at 11.05am.
On Fridays and Sundays, flights will depart Isle of Man at 3.30pm, arriving Heathrow at 4.45pm. Return flights will depart Heathrow at 5.35pm, arriving Isle of Man at 6.50pm.
Loganair chief executive Jonathan Hinkles said: "We are heartened to be able to restore the Isle of Man’s connectivity to Heathrow, building on our record of delivering the island’s essential passenger air services through the Covid-19 pandemic.
"It represents an excellent springboard for future developments as and when circumstances allow, and this will include creation of local employment in the Isle of Man to fly Loganair’s services."
Loganair operates Isle of Man routes to Liverpool and Manchester, with an Isle of Man pilot and cabin crew base and locally-contracted maintenance service.
