The Scottish carrier took over the daily London City route from British Airways at the start of September on an interim basis.
From 1 December, however, flights will instead operate from Heathrow, offering travellers a greater range of connections.
The route is Loganair’s first permanent scheduled service to and from Heathrow, and will be operated using a 49-seat Embraer 145 jet.
Fares lead in from £69.99pp one way, with Saturday flights set to be introduced from 19 December.