The reported loss for the full-year ending 30 September compared with a £430 million profit in 2019.
However, the airline said with its "unmatched network, leaner cost base, most trusted brand and strong liquidity, after raising more than £3.1 billion to date", easyJet is "strongly positioned to be a leader in the recovery of the European airline".
Passenger numbers for the period decreased by 50% to 48.1 million (2019: 96.1 million), with capacity decreasing by 47.5%.
Load factor "only decreased by 4.3 percentage points" to 87.2% due to a "prudent approach to capacity".
Total revenue decreased by 52.9% to £3.1 billion (2019: £6.39 billion).