KLM will restart operations at London City airport next month.
The Dutch carrier’s services to Amsterdam Schiphol will resume on 13 July.
It comes after BA CityFlyer relaunch flights to and from the Docklands airport on Sunday (21 June).
KLM will initially operate a single daily service, before increasing frequency when demand returns.
Flights will allow passengers to connect to more than 100 onward destinations.
Services will be operated by subsidiary KLM Cityhopper using a 100-passenger Embraer 190 aircraft
KLM will insist on the compulsory wearing of face masks for all passengers, crew, and airport ground handlers; physical distancing will be enforced throughout the customer journey; while aircraft will be subject to more rigorous cleaning and disinfection regimes.
In-flight service will be limited, with mea and drinks services suspend on domestic and short flights in Europe.
Benedicte Duval, KLM general manager UK and Ireland, said safety was a "prerequisite" for KLM. "Pre-Covid, we were operating up to nine [London City] flights a day so we look forward to increasing capacity in line with demand over the coming months."
Richard Hill, London City chief commercial officer, added: “KLM’s return to London City airport is another positive sign of recovery as we resume passenger flights.
"We have been working hard with our airline partners to re-establish routes and this is an important milestone, restoring a very popular connection between two of Europe’s most important cities.
"With the UK government looking likely to announce air bridges soon, and given the significance and popularity of this connection, it’s crucial that the Netherlands is covered."