Syed is leaving to “pursue external opportunities”, the company said, with Mottershead taking over on October 1.
Syed will stay with the business until October 31.
In a statement released today, Thomas Cook chief executive Peter Fankhauser said: “Next year marks the 175th anniversary of our company, and Chris is the ideal person to lead the UK business into the next chapter in its history.
"He enjoys an excellent reputation, with a well-proven vision of meeting the needs of customers in an omni-channel, technology-driven world.
Thomas Cook announces new UK MD
Sophie Griffiths
28 September 2015
Chris Mottershead is to replace Salman Syed as the UK managing director of Thomas Cook.
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